<i>Dioscorea alata</i> (Water Yam Peel) Extract Could Improves Hepatic and Renal Tissue Functioning in Tramadol-Treated Albino Rats

Abstract

Background/Objective: The white yam, or Dioscorea alata, is a plant that has been shown to be high in both nutrients and anti-nutrients. The plant offers a wealth of therapeutic qualities, according to numerous studies. Analgesics that are synthetic opioids and used to treat moderate to severe pain include tramadol. The aim was to determine the beneficial effects of Dioscorea on the liver and kidney tissues of Wistar rats who had received tramadol treatment. Materials and Methods: The animals were divided into five groups. Group one serve as control while group to received 200mg / kg of tramadol, group 3 to five received D. alata of 200 mg / kg body weight, 300 mg/kg body weight of D. alata for the following 7 days, and 20 mg / kg body weight of tramadol once daily, 500 mg/kg body weight of D. alata extract taken orally for 7 days and 20 mg / kg of tramadol body weight once daily for 7 days respectively. Results and conclusion: The Statistical Package for Social Sciences, version 20, was used to analyze the data that was produced. There was a statistically significant difference in the in-Aspartate transaminase (AST) when compare to the other groups. Groups 4 and 5 showed a statistically significant rise in potassium values (P<0.05) when compare to group 1. Our findings also show that, the kidney and liver tissues are inflamed. Dioscorea alata hepatoprotective, antioxidant, and nephroprotective effects on the tissues. The results of the study suggest that Dioscorea alata may be able to ameliorate renal and hepatic damages from tramadol use.