Protective Effects of Cellgevity® Against High Fructose Diet-Induced Kidney Dysfunction and Hyperuricaemia in Wistar Rats

Abstract

Background: High fructose intake contributes to kidney dysfunction and elevated uric acid levels. Polyherbal supplements like Cellgevity® may offer protective benefits but have remained underexplored. This study evaluated the protective effect of Cellgevity® against kidney dysfunction and hyperuricaemia in rats fed a high-fructose diet.

Materials and Methods: Twenty male Wistar rats (180 - 220 g) were divided into four groups of five rats each: the control (normal diet), 60% High Fructose Diet (HFD) + 10% Fructose Water (FW), HFD+FW + Atorvastatin (3.52 mg/kg body weight), and HFD+FW + Cellgevity® (161.27 mg/kg body weight) groups. The feed and water were given ad libitum, while the Atorvastatin and Cellgevity® were dissolved in distilled water and administered using an oro-gastric gavage. After 28 experimental days, the rats were sacrificed and blood samples collected for estimation of electrolytes, urea, and creatinine and uric acid levels, using standard assay protocols. The results were analyzed by one-way ANOVA and Tukey’s post hoc tests, using the Statistical Package for Social Sciences-20 software. Tissue histology of the rat’s kidneys were also assessed.

Results: The HFD+FW group showed significantly higher (P<0.05) levels of urea (34.52±1.71), sodium (152.10±2.15) and uric acid (4.99±0.27) compared with the control group. Cellgevity® prevented significantly (P<0.05), these increases in urea (25.74±0.82), sodium (138.90±1.10), and uric acid (1.16±0.28). The HFD caused focal tubular necrosis, interstitial congestion, interstitial infiltrates of inflammatory cells, in the kidneys of the rats, while Cellgevity® protected the kidneys against such changes.

Conclusion: Cellgevity® demonstrated promise in protecting against high-fructose diet-induced renal dysfunction and hyperuricaemia in Wistar rats.