Protective Effects of Glycine against Cadmium Chloride-Induced Gastric Toxicity in Wistar Rats

Abstract

Background: Heavy metal poisoning poses significant health risk to both human and animal subjects. Increased human activities and industrialization have led to increased exposure to these heavy metals. This study investigated the potential of glycine in ameliorating cadmium chlorinde-induced toxicity on gastric tissues of Wistar rats.

Methods: Thirty adult male Wistar rats weighing between 150 and 170g were randomly assigned into six groups of five rats per group and received 1 ml of distilled water (control), 10 mg/kg body weight of Cadmium chloride, 500 mg/kg body weight of Glycine, 1000 mg/kg body weight of Glycine, 10 mg/kg body weight of Cadmium chloride and 500 mg/kg body weight of Glycine, 10 mg/kg body weight of Cadmium chloride and 1000 mg/kg body weight of Glycine respectively. Cadmium and Glycine were administered orally for 14 days. Rats stomach were harvested and analyzed for Malondialdehyde(MDA), Superoxide Dismutase(SOD), Catalase(CAT), Glutathione Peroxidase(GPx) and histological examination.

Results: The mean body weight and the SOD level in rats treated with cadmium chloride were significantly decreased (p < 0.05). The MDA level was significantly increased with cadmium chloride but significantly reduced with Glycine treatment (p < 0.05). The CAT and GPx levels were significantly increased with Glycine treatment. Histological examination of rats stomach revealed evidence of Glycine mitigation in Cadmium chloride-induced gastric damage in Wistar rats.

Conclusion: Glycine possesses anti-inflammatory, antioxidant and ameliorative potentials against cadmium chloride-induced gastric damage in Wistar rats.